Understanding how protective proteins interact with harmful peptides in diseases like Alzheimer's
Official title: Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging
Funded at University of Delaware · NIH-11018377 · Data updated 2026-11-12
This study is looking at how special proteins that help protect our cells interact with harmful pieces of proteins linked to Alzheimer's, using advanced imaging techniques to better understand these interactions, which could help create new treatments for the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $235,261 |
| NIH project number | 1P20GM156674-01 |
| Project ID | NIH-11018377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or other amyloid-related disorders.
✕Less likely to help
Patients with non-amyloid related forms of dementia or those without amyloid-related conditions may not benefit from this research.
What this research studies
This research investigates the interactions between protective chaperone proteins and amyloidogenic peptides, which are linked to diseases such as Alzheimer's. By utilizing advanced two-dimensional infrared (2DIR) imaging techniques, the study aims to uncover how these proteins bind to different forms of harmful peptides. This could lead to the development of targeted therapies that enhance the protective effects of chaperones against amyloid diseases. The research focuses on improving imaging methods to gain insights into the structural changes of these proteins and peptides during their interactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect against Alzheimer's disease and other amyloid-related conditions.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study protein interactions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Alperstein, Ariel Martelle — University of Delaware
- Study coordinator: Alperstein, Ariel Martelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.