Understanding how proteasome regulation affects heart health
Official title: Cardiac Pathophysiology of Proteasome Phosphoregulation
Funded at University of South Dakota · NIH-10627948 · Data updated 2026-11-12
This study is looking at how certain proteins in the heart can be changed to help improve heart function, with the goal of finding new treatments for people with heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Dakota NIH-funded |
| Lab location | 1 site (Vermillion, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $367,500 |
| NIH project number | 5R01HL153614-04 |
| Project ID | NIH-10627948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart diseases or conditions that may lead to heart failure.
✕Less likely to help
Patients with non-cardiac related health issues or those without heart disease may not benefit from this research.
What this research studies
This research investigates the role of the ubiquitin-proteasome system in heart diseases, focusing on how the phosphorylation of specific proteins can enhance proteasome activity. By studying the mechanisms that regulate proteasome function, the researchers aim to develop new pharmacological strategies to treat heart conditions. The approach includes genetic studies in mice to observe changes in proteasome activity related to heart stress and damage. This could lead to innovative treatments for patients suffering from heart disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and outcomes for patients with heart disease.
How similar studies have gone: Previous research has shown promise in enhancing proteasome function as a therapeutic strategy, indicating potential for success in this area.
Where this research is happening
-
University of South Dakota
Vermillion, United States Active
Researchers
- Principal investigator: Wang, Xuejun — University of South Dakota
- Study coordinator: Wang, Xuejun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.