Understanding how prostate cancer spreads to bones
Project 2: Investigating cell intrinsic and extrinsic drivers of prostate cancer bone metastasis
This study is looking at how prostate cancer spreads to bones, using a special mouse model to understand the role of genes and signals in this process, with the goal of finding new treatment options for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11078872 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that allow prostate cancer cells to spread to bones, focusing on both the cancer cells themselves and their surrounding environment. Using a specialized mouse model that mimics human prostate cancer bone metastasis, the team will explore how certain genetic factors and signaling pathways contribute to this process. By analyzing changes in the cancer cells and their interactions with the bone environment, the research aims to identify potential targets for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with prostate cancer who are at risk of or have developed bone metastases.
Not a fit: Patients with prostate cancer that has not metastasized to the bones may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or treat bone metastasis in prostate cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding cancer metastasis using similar genetic and environmental approaches.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Abate-Shen, Cory — Columbia University Health Sciences
- Study coordinator: Abate-Shen, Cory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.