Understanding how prostate cancer spreads to bones
Interplay between tumor and microenvironment in bone metastasis
This study is looking at how prostate cancer spreads to bones and testing a new treatment that could help improve care for patients with advanced prostate cancer that has spread to their bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11053338 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which prostate cancer metastasizes to bone, focusing on the interactions between cancer cells and the bone environment. The team will utilize a pre-clinical model to explore the role of specific genes in promoting cancer invasion and to evaluate a new small molecule inhibitor aimed at targeting both the cancer cells and the bone niche. By developing innovative therapeutic strategies, the research aims to improve treatment outcomes for patients with advanced prostate cancer and bone metastases.
Who could benefit from this research
Good fit: Ideal candidates for this research are men over the age of fifty who have been diagnosed with advanced prostate cancer and are experiencing bone metastases.
Not a fit: Patients with localized prostate cancer that has not spread to the bones may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for prostate cancer that has spread to the bones, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting cancer metastasis through innovative therapeutic approaches, suggesting that this line of investigation could yield significant advancements.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Fisher, Paul B — Virginia Commonwealth University
- Study coordinator: Fisher, Paul B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.