Understanding how prostate cancer spreads
Mechanisms of Prostate Cancer Metastasis
This study is looking at how aggressive prostate cancer spreads and changes when it becomes resistant to treatments, with the goal of finding new ways to stop these tough cancer cells from growing and spreading, so it can help patients facing this challenge.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10926881 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the spread of aggressive prostate cancer, particularly focusing on a process called lineage plasticity that occurs when cancer cells become resistant to certain therapies. By studying how these cancer cells change and adapt, researchers aim to identify new targets for treatment, including a novel class of small molecule inhibitors that can potentially stop the growth and spread of these resistant cancer cells. The research utilizes advanced models and genomic data to explore the biological changes in prostate cancer tissues and circulating tumor cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include men diagnosed with aggressive or castration-resistant prostate cancer who are experiencing treatment resistance.
Not a fit: Patients with early-stage prostate cancer or those who have not undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target and inhibit the spread of aggressive prostate cancer.
How similar studies have performed: Previous research has shown promising results in targeting similar mechanisms in cancer, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Freeman, Michael R — Cedars-Sinai Medical Center
- Study coordinator: Freeman, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.