Understanding how prostate cancer responds to and resists new treatments.
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
This study is looking at how advanced prostate cancer cells react to new drugs called PARP inhibitors, with the goal of finding better ways to treat patients by understanding why some cells resist these treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10874695 on NIH RePORTER |
What this research studies
This research focuses on improving treatments for advanced prostate cancer by investigating how certain cancer cells respond to PARP inhibitors, a new class of drugs. The study aims to identify the mechanisms behind both the effectiveness and resistance of these treatments in prostate cancer patients. By developing specific cancer cell models that mimic resistance to these drugs, the research seeks to uncover critical insights that could lead to better therapeutic strategies. The principal investigator, Dr. Alan Lombard, is being mentored to become an independent researcher in this field.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced prostate cancer who may benefit from PARP inhibitor therapies.
Not a fit: Patients with early-stage prostate cancer or those not eligible for PARP inhibitor treatments may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with advanced prostate cancer.
How similar studies have performed: Previous research has shown promising results with PARP inhibitors in other cancers, indicating potential for success in prostate cancer as well.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lombard, Alan — University of California at Davis
- Study coordinator: Lombard, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.