Understanding how prostate cancer resists hormone therapy in low oxygen conditions

Who could benefit from this research

What this research studies

This research investigates how prostate cancer cells develop resistance to hormone therapies, particularly in low oxygen environments. The focus is on a specific enzyme called GPT1, which may play a crucial role in how cancer cells adapt their metabolism to survive despite treatment. By studying the mechanisms behind this resistance, the research aims to identify new strategies to improve the effectiveness of existing therapies. Patients may benefit from insights that could lead to more effective treatments for advanced prostate cancer.

Why it matters

Where this research is happening

• Oregon Health & Science University
  Portland, United States Active

Researchers

• Principal investigator: Qian, Zheng David — Oregon Health & Science University
• Study coordinator: Qian, Zheng David

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.