Understanding how prostate cancer changes when it becomes resistant to treatment
Investigating lineage plasticity in castration-resistant prostate cancer
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10878995
This study is looking at how prostate cancer can become tougher and stop responding to common treatments, using special mouse models and lab-grown cells to learn more about the changes that happen in the cancer cells, which could help find better ways to treat it in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10878995 on ClinicalTrials.gov |
What this research studies
This research investigates how prostate cancer evolves into more aggressive forms that resist standard anti-androgen treatments. By studying genetically-engineered mouse models and organoid cultures, the team aims to uncover the mechanisms behind lineage plasticity in castration-resistant prostate cancer (CRPC). They utilize advanced techniques like single-cell RNA sequencing to analyze the genetic and epigenetic changes that occur during this transformation. The goal is to better understand the cellular differentiation processes that lead to treatment resistance, which could inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with castration-resistant prostate cancer who have previously undergone anti-androgen therapy.
Not a fit: Patients with early-stage prostate cancer or those who have not received anti-androgen treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that effectively target the aggressive forms of prostate cancer.
How similar studies have performed: Previous research has shown promising results in understanding lineage plasticity in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, MICHAEL M. — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SHEN, MICHAEL M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.