Understanding how prostate cancer changes from one type to another
Official title: Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation
Funded at Emory University · NIH-10982139 · Data updated 2026-11-12
This study is looking at how prostate cancer changes into a tougher form called neuroendocrine prostate cancer, and it's for anyone interested in understanding what happens at the cellular level during this transformation, which could help find new treatments and ways to track the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $541,236 |
| NIH project number | 1R01CA286147-01A1 |
| Project ID | NIH-10982139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with prostate adenocarcinoma who may be at risk of developing neuroendocrine prostate cancer.
✕Less likely to help
Patients with non-prostate cancers or those whose prostate cancer has already progressed to neuroendocrine type may not benefit from this research.
What this research studies
This research investigates the molecular changes that occur when prostate adenocarcinoma transforms into neuroendocrine prostate cancer, a more aggressive form of the disease. By studying specific genes and their effects on cell behavior over time, researchers aim to uncover the biological mechanisms driving this transformation. The approach involves manipulating prostate cancer cells in the lab to observe changes in gene expression and cellular structure, which may reveal potential targets for new treatments and biomarkers for disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options and diagnostic tools for patients with neuroendocrine prostate cancer.
How similar studies have gone: While the specific approach of studying luminal-to-neuroendocrine transdifferentiation is novel, similar research has shown promise in understanding cancer progression and identifying treatment targets.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Zhao, Changsheng — Emory University
- Study coordinator: Zhao, Changsheng
Related research
Other NIH-funded projects on the same topics.
-
Administrative and Engagement Core for Breast Cancer Breakthrough in Kenya
A national effort in Kenya to speed up how we screen for breast cancer and connect women to treatment, using teamwork across institutions.
-
Collaborative research program to advance patient care
A multi-project research effort at Emory University aims to push forward medical knowledge that could help people with illnesses in the future.
-
Project-003: A multi-partner research program at Emory University
A multi-faceted NIH grant at Emory University aims to advance understanding in a focused area over several years to benefit patients with diseases or conditions connected to the research.
-
Project-002: advancing patient care through coordinated research at Emory
A multi-project NIH grant at Emory aims to translate findings into better care for people with a health condition by coordinating research efforts across teams.
-
Project-006: A Multidisciplinary Emory Initiative to Advance Medical Understanding
A multi-project NIH grant at Emory University aims to push forward medical knowledge in areas that could eventually help patients.
-
Project-005: A multi-component research effort at Emory University
A multi-part NIH grant from Emory University aims to advance understanding in a specific health area over several years with potential patient benefits in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.