Understanding how prostate cancer changes from one type to another
Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation
This study is looking at how prostate cancer changes into a tougher form called neuroendocrine prostate cancer, and it's for anyone interested in understanding what happens at the cellular level during this transformation, which could help find new treatments and ways to track the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10982139 on NIH RePORTER |
What this research studies
This research investigates the molecular changes that occur when prostate adenocarcinoma transforms into neuroendocrine prostate cancer, a more aggressive form of the disease. By studying specific genes and their effects on cell behavior over time, researchers aim to uncover the biological mechanisms driving this transformation. The approach involves manipulating prostate cancer cells in the lab to observe changes in gene expression and cellular structure, which may reveal potential targets for new treatments and biomarkers for disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with prostate adenocarcinoma who may be at risk of developing neuroendocrine prostate cancer.
Not a fit: Patients with non-prostate cancers or those whose prostate cancer has already progressed to neuroendocrine type may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options and diagnostic tools for patients with neuroendocrine prostate cancer.
How similar studies have performed: While the specific approach of studying luminal-to-neuroendocrine transdifferentiation is novel, similar research has shown promise in understanding cancer progression and identifying treatment targets.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Zhao, Changsheng — Emory University
- Study coordinator: Zhao, Changsheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.