Understanding how prostate cancer changes and resists treatment using blood tests and advanced genetic techniques
Official title: Mapping the epigenetic dynamics of prostate cancer progression: integrating liquid biopsies and single-cell epigenomics for early detection of lineage plasticity and clinical decision-making
Funded at Dana-Farber Cancer Inst · NIH-11106139 · Data updated 2026-11-12
This study is looking at how prostate cancer changes and becomes tougher to treat over time, and it’s for patients who want to help researchers find better ways to detect and treat their cancer by providing blood samples for analysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $627,474 |
| NIH project number | 1R01CA300092-01 |
| Project ID | NIH-11106139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced prostate cancer, particularly those experiencing treatment resistance.
✕Less likely to help
Patients with early-stage prostate cancer or those not undergoing treatment may not benefit from this research.
What this research studies
This research investigates the changes in prostate cancer as it progresses, particularly focusing on how the cancer adapts and becomes resistant to treatments. By analyzing blood samples and using advanced single-cell epigenomic techniques, the study aims to identify specific changes in the cancer's genetic makeup that could help in early detection and treatment decisions. Patients may provide blood samples that will be analyzed to understand the cancer's behavior and response to therapies. The goal is to improve outcomes for patients with advanced prostate cancer by tailoring treatments based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of aggressive prostate cancer and more effective personalized treatment strategies.
How similar studies have gone: Other research has shown promising results using similar epigenomic approaches to understand cancer progression and treatment resistance.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Freedman, Matthew L — Dana-Farber Cancer Inst
- Study coordinator: Freedman, Matthew L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.