Understanding how prostate cancer cells interact with their environment at a single cell level
Investigating cell-intrinsic and extrinsic interactions in prostate cancer at the single cell level
This study is looking at how prostate cancer cells interact with their surroundings to understand why the cancer grows and sometimes doesn’t respond to treatment, and it’s designed for anyone affected by prostate cancer who wants to learn more about what’s happening in their body.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11078867 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between prostate cancer cells and their surrounding environment, focusing on how these interactions contribute to cancer progression and treatment resistance. By utilizing advanced single-cell techniques, the study aims to uncover the diverse cell types and states involved in tumor development. A multi-institutional team of experts will collaborate on various projects to explore immune and stromal factors that influence prostate cancer behavior, particularly in relation to metastasis and response to therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include men diagnosed with prostate cancer, particularly those experiencing progression to metastatic disease.
Not a fit: Patients with non-prostate cancers or those who are not currently undergoing treatment for prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for prostate cancer by identifying new therapeutic targets and strategies.
How similar studies have performed: Previous research using single-cell approaches in cancer has shown promising results, indicating that this methodology could yield valuable insights into prostate cancer.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Shen, Michael M. — Columbia University Health Sciences
- Study coordinator: Shen, Michael M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.