Understanding how prostate cancer cells change to resist treatment
Molecular mechanisms driving therapy-induced lineage plasticity
This study is looking at how prostate cancer cells change and become tougher against treatments, especially in cases where the cancer doesn't respond to hormone therapy, to help find better ways to fight these more aggressive forms of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10931650 on NIH RePORTER |
What this research studies
This research investigates the molecular and cellular mechanisms that allow prostate cancer cells to adapt and become resistant to therapies. By studying castration-resistant prostate cancer (CRPC), the research aims to uncover how these cells evade treatment and differentiate into more aggressive forms. The approach involves using advanced mouse models that mimic human disease and applying bioinformatics tools for detailed epigenetic analysis. This work is crucial for developing new strategies to combat aggressive prostate cancer variants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with castration-resistant prostate cancer who are experiencing treatment resistance.
Not a fit: Patients with early-stage prostate cancer or those who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that effectively target and manage aggressive forms of prostate cancer.
How similar studies have performed: Other research has shown promising results in understanding cancer cell plasticity, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Linares Rodriguez, Juan Francisco — Weill Medical Coll of Cornell Univ
- Study coordinator: Linares Rodriguez, Juan Francisco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.