Understanding how prostate cancer affects surrounding tissue
Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11051865
This study is looking at how a specific protein called the androgen receptor affects prostate cancer and its surrounding tissue, using a special model to see how losing this protein might help the cancer grow, which could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11051865 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the androgen receptor (AR) in both prostate cancer cells and the surrounding stromal tissue. By using a unique Prostate-on-Chip model, researchers aim to understand how the loss of AR in the stroma contributes to prostate cancer development. The study will explore the mechanisms by which tumor-derived factors suppress AR expression in the stroma and how this loss impacts the normal function of prostate tissue. Patients may benefit from insights that could lead to new therapeutic strategies targeting stromal interactions in prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with prostate cancer, particularly those interested in understanding the disease's mechanisms.
Not a fit: Patients with benign prostate conditions or those who do not have prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better target prostate cancer by addressing the surrounding tissue's role in disease progression.
How similar studies have performed: While the approach of using a Prostate-on-Chip model is innovative, similar studies have shown promise in understanding cancer biology through engineered tissue models.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIRANTI, CYNTHIA K — UNIVERSITY OF ARIZONA
- Study coordinator: MIRANTI, CYNTHIA K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Basic Cancer Research