Understanding how propionate metabolism affects cancer spread
Propionate metabolism and cancer
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11055311
This study is looking at how the way cancer cells use certain nutrients might help them become more aggressive and spread in the body, which could lead to new ways to treat cancer and help patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11055311 on ClinicalTrials.gov |
What this research studies
This research investigates the role of propionate metabolism in the progression of cancer, particularly how tumor cells transition to a more invasive state known as epithelial-to-mesenchymal transition (EMT). By analyzing changes in proteins, metabolites, and gene expression during this process, the study aims to uncover new mechanisms that contribute to cancer metastasis. Patients may benefit from insights gained about how metabolic changes can influence cancer behavior, potentially leading to new therapeutic strategies. The research employs advanced techniques such as proteomics and metabolomics to gather comprehensive data on cellular changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-metastatic cancers or those not undergoing treatment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to predict and prevent cancer metastasis, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown promise in understanding metabolic factors in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BLENIS, JOHN — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: BLENIS, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy