Understanding how proline metabolism affects heart cell growth.
Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte Proliferation
This study is looking at how a substance called proline helps heart cells grow and heal, especially when the heart is struggling, and it hopes to find ways to boost the heart's ability to repair itself, which could lead to better treatments for heart failure.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10897868 on NIH RePORTER |
What this research studies
This research investigates the role of proline metabolism in the growth and regeneration of heart cells, particularly in the context of heart failure. It focuses on how the heart's ability to replace damaged cells diminishes after birth and explores mechanisms that could enhance this regenerative capacity. By studying the effects of hypoxia (low oxygen levels) on heart cells, the research aims to identify factors that promote cell division and repair in the heart. Patients may benefit from insights that could lead to new treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or related cardiac conditions.
Not a fit: Patients with acute heart conditions or those who are not experiencing heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance heart cell regeneration and improve outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding heart cell regeneration, but this specific approach focusing on proline metabolism is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Sadek, Hesham — University of Alabama at Birmingham
- Study coordinator: Sadek, Hesham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.