Understanding how progranulin affects TDP-43 protein issues in neurodegenerative diseases
Investigating the role of progranulin in TDP-43 proteinopathy
This study is looking at how a protein called progranulin affects another protein linked to diseases like Alzheimer's and ALS, using mice to see how changes in progranulin levels might influence behavior and brain health, with the hope of finding new ways to help people with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10510687 on NIH RePORTER |
What this research studies
This research investigates the role of progranulin, a protein linked to neurodegenerative diseases like Alzheimer's and frontotemporal lobar degeneration. The study uses a mouse model to explore how changes in progranulin levels affect TDP-43 protein, which is associated with these diseases. Researchers will examine the effects of progranulin deficiency and overexpression on TDP-43 function and related behavioral changes. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for conditions like ALS and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting progranulin or those diagnosed with Alzheimer's disease or frontotemporal lobar degeneration.
Not a fit: Patients with neurodegenerative diseases not related to TDP-43 proteinopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases that currently have limited options.
How similar studies have performed: Previous research has shown promising results in understanding TDP-43 proteinopathy, but this specific approach focusing on progranulin is relatively novel.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Hu, Fenghua — Cornell University
- Study coordinator: Hu, Fenghua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.