Understanding how progesterone receptors interact with other proteins
Structural dynamics of progesterone receptor-coactivator complexes
This study is looking at how progesterone receptors work and interact with other proteins in the body, which is important for understanding how hormones affect different conditions, and it aims to help patients by revealing new insights into these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11080779 on NIH RePORTER |
What this research studies
This research investigates the structural dynamics of progesterone receptors and their interactions with coactivator proteins, which are crucial for regulating gene expression in response to steroid hormones. By examining the conformational changes of these receptors, the study aims to uncover how different isoforms of the progesterone receptor function in various tissues and conditions. The approach involves high-resolution structural analysis to visualize these interactions and understand their implications for hormone signaling. Patients may benefit from insights gained into how these mechanisms affect conditions influenced by progesterone.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with hormone-related conditions, particularly those affected by progesterone signaling.
Not a fit: Patients with conditions unrelated to hormone signaling or those not affected by progesterone may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to progesterone signaling, such as certain cancers and reproductive disorders.
How similar studies have performed: Previous research has shown success in understanding steroid hormone receptor dynamics, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Griffin, Patrick Robert — University of Florida
- Study coordinator: Griffin, Patrick Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.