Understanding how PRMT9 affects brain development and function
Biological function and regulation of PRMT9 in synapse development
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-11026448
This study is looking at how a protein called PRMT9 helps with brain development by affecting the way genes are processed, and it's for anyone interested in understanding more about the causes of certain intellectual disabilities linked to changes in this protein.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-11026448 on ClinicalTrials.gov |
What this research studies
This research investigates the role of PRMT9, a protein that modifies RNA-binding proteins, in regulating pre-mRNA splicing, which is crucial for proper brain development and function. By studying how mutations in PRMT9 affect its ability to modify another protein, SF3B2, the research aims to uncover the molecular mechanisms behind synapse development. The team will use a conditional knockout mouse model to observe the effects of PRMT9 loss on brain function and development, providing insights that could lead to new therapeutic strategies for intellectual disabilities linked to PRMT9 mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autosomal recessive intellectual disabilities linked to mutations in the PRMT9 gene.
Not a fit: Patients without mutations in the PRMT9 gene or those with different types of intellectual disabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for intellectual disabilities caused by mutations in PRMT9.
How similar studies have performed: Previous research has shown that understanding the role of protein modifications in RNA splicing can lead to significant advancements in treating related neurological conditions.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YANZHONG — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: YANG, YANZHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.