Understanding how PRMT9 affects brain development and function
Official title: Biological function and regulation of PRMT9 in synapse development
Funded at Beckman Research Institute/city of Hope · NIH-11026448 · Data updated 2026-11-12
This study is looking at how a protein called PRMT9 helps with brain development by affecting the way genes are processed, and it's for anyone interested in understanding more about the causes of certain intellectual disabilities linked to changes in this protein.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | February 5, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $535,402 |
| NIH project number | 5R01NS132083-02 |
| Project ID | NIH-11026448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autosomal recessive intellectual disabilities linked to mutations in the PRMT9 gene.
✕Less likely to help
Patients without mutations in the PRMT9 gene or those with different types of intellectual disabilities may not benefit from this research.
What this research studies
This research investigates the role of PRMT9, a protein that modifies RNA-binding proteins, in regulating pre-mRNA splicing, which is crucial for proper brain development and function. By studying how mutations in PRMT9 affect its ability to modify another protein, SF3B2, the research aims to uncover the molecular mechanisms behind synapse development. The team will use a conditional knockout mouse model to observe the effects of PRMT9 loss on brain function and development, providing insights that could lead to new therapeutic strategies for intellectual disabilities linked to PRMT9 mutations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for intellectual disabilities caused by mutations in PRMT9.
How similar studies have gone: Previous research has shown that understanding the role of protein modifications in RNA splicing can lead to significant advancements in treating related neurological conditions.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Yang, Yanzhong — Beckman Research Institute/city of Hope
- Study coordinator: Yang, Yanzhong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.