Understanding how PRMT7 affects gene expression in development
Official title: Role of PRMT7 in Genomic Imprinting
Funded at University of Tx Md Anderson Can Ctr · NIH-11093525 · Data updated 2026-11-12
This study is looking at how a specific protein called PRMT7 affects the way genes from our parents are expressed, which could help us understand issues related to fertility and certain developmental disorders, so that people trying to conceive or facing these conditions might find helpful information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 17, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $348,300 |
| NIH project number | 5R01HD112473-03 |
| Project ID | NIH-11093525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing difficulty conceiving or those with developmental disorders potentially linked to genomic imprinting.
✕Less likely to help
Patients who do not have issues related to fertility or developmental disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of PRMT7, an arginine methyltransferase, in genomic imprinting, which is a process that influences how certain genes are expressed based on their parental origin. The study focuses on understanding how DNA methylation patterns are established and maintained during gamete formation and embryonic development. By examining the effects of PRMT7 on these processes, researchers aim to uncover the mechanisms behind gene regulation that could impact fertility and developmental disorders. Patients may benefit from insights gained into the genetic factors affecting their ability to conceive or develop certain conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing infertility and developmental disorders linked to genomic imprinting.
How similar studies have gone: Previous research has shown promising results in understanding the role of DNA methylation in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Chen, Taiping — University of Tx Md Anderson Can Ctr
- Study coordinator: Chen, Taiping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.