Understanding how prior infections affect immune responses in HIV
Mechanisms of Trained Immunity in HIV Immune Responses
This study is looking at how past infections can help your immune system better fight HIV, and it also explores how things like substance use might change this response, with the goal of finding better treatments for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10665784 on NIH RePORTER |
What this research studies
This research investigates how the innate immune system can be 'trained' by previous infections, particularly in the context of HIV. It focuses on how these trained immune responses can influence the body's ability to fight HIV and how factors like substance use may affect these responses. By examining the epigenetic changes in immune cells, the research aims to uncover mechanisms that could lead to improved treatments for HIV. Patients may benefit from insights that could enhance their immune responses against the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those who have experienced acute infection.
Not a fit: Patients who are not infected with HIV or those who have advanced HIV disease with limited immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses in HIV patients.
How similar studies have performed: While the concept of trained immunity is gaining attention, the specific application to HIV is relatively novel and has not been extensively tested in prior research.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Fulcher, Jennifer — University of California Los Angeles
- Study coordinator: Fulcher, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.