Understanding how prior experiences influence decision-making in rats and humans

CRCNS: Circuit mechanisms of priors and learning during decision making

NIH-funded research Massachusetts Institute of Technology · NIH-10896997

This study looks at how both rats and people learn new tasks and make choices, especially how past decisions can shape current ones, which might not always lead to the best results, and it aims to understand the brain processes behind these behaviors.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMassachusetts Institute of Technology NIH-funded
Lab location1 site (Cambridge, United States)
Project IDNIH-10896997 on NIH RePORTER

What this research studies

This research investigates how both rats and humans learn new tasks and make decisions, focusing on the biases that can affect their performance. It explores the concept of sequential effects, where past choices influence current decisions, potentially leading to suboptimal outcomes. By comparing the behavior of animals with recurrent neural networks (RNNs) that have been programmed with evolutionary learning strategies, the study aims to uncover the neural mechanisms behind these decision-making processes. The research will involve characterizing these effects during learning tasks and identifying the neural circuitry involved.

Who could benefit from this research

Good fit: Ideal candidates for participation or benefit from this research would include individuals interested in cognitive processes and decision-making, particularly those with conditions that affect learning and behavior.

Not a fit: Patients with conditions unrelated to cognitive function or decision-making may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could enhance our understanding of decision-making processes, potentially leading to improved strategies for learning and behavior in both humans and animals.

How similar studies have performed: Previous research has shown success in using neural network models to understand cognitive processes, suggesting that this approach may yield valuable insights.

Where this research is happening

Cambridge, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.