Understanding how primary cilia maintain their structure and function
Official title: Intraflagellar transport process in primary cilium maintenance
Funded at Wadsworth Center · NIH-10873947 · Data updated 2026-11-12
This study is looking at how tiny transport trains inside cells help build and keep healthy primary cilia, which are important for sensing signals that control cell growth, and it aims to find out more about conditions related to cilia problems, so patients with these issues can get better insights into their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wadsworth Center NIH-funded |
| Lab location | 1 site (Menands, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $349,043 |
| NIH project number | 5R01GM143223-04 |
| Project ID | NIH-10873947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with ciliopathies or related developmental abnormalities.
✕Less likely to help
Patients without any known ciliary dysfunction or related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of intraflagellar transport (IFT) in the assembly and maintenance of primary cilia, which are essential cellular structures that help detect signals for cell growth and proliferation. By examining how IFT trains move along the cilia and contribute to their structure, the research aims to uncover the mechanisms behind various medical disorders linked to ciliary dysfunction. Patients may benefit from insights gained about ciliopathies, which are conditions caused by problems in cilia function. The study employs advanced imaging techniques to visualize these processes in detail.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for a range of disorders associated with ciliary dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding ciliary function and its implications for various diseases, indicating that this approach has potential for success.
Where this research is happening
-
Wadsworth Center
Menands, United States Active
Researchers
- Principal investigator: Sui, Haixin — Wadsworth Center
- Study coordinator: Sui, Haixin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.