Understanding how primary cilia contribute to abnormal bone growth
The essential roles of primary cilia in heterotopic ossification
This study is looking at how tiny structures in our cells, called primary cilia, might affect the unusual growth of bone in soft tissues, which can happen in conditions like fibrodysplasia ossificans progressiva (FOP), and the researchers hope to find new ways to help people dealing with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10916502 on NIH RePORTER |
What this research studies
This research investigates the role of primary cilia in the process of heterotopic ossification (HO), which is the abnormal formation of bone in soft tissues. The study focuses on both hereditary and nonhereditary forms of HO, including a rare genetic condition known as fibrodysplasia ossificans progressiva (FOP). By using novel models, the researchers aim to uncover how primary cilia influence the bone morphogenetic protein (BMP) signaling pathway, which is crucial for bone formation. The ultimate goal is to develop new treatment strategies for patients affected by HO.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary or nonhereditary forms of heterotopic ossification, particularly those with fibrodysplasia ossificans progressiva.
Not a fit: Patients with conditions unrelated to bone formation or those without any form of heterotopic ossification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for patients suffering from heterotopic ossification.
How similar studies have performed: Previous research has shown promising results in understanding the BMP signaling pathway, but the specific role of primary cilia in HO is still being explored and represents a novel approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Wang, Haitao — Mayo Clinic Rochester
- Study coordinator: Wang, Haitao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.