Understanding how primary cilia are formed and broken down in cells
Mechanisms of Primary Cilium Assembly and Disassembly
This study is looking at tiny structures called cilia that are found on most of our cells, which help keep our bodies healthy and develop properly, and it's for anyone interested in how these cilia work and their connection to diseases like childhood illnesses and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10885100 on NIH RePORTER |
What this research studies
This research investigates the primary cilium, a small structure on most human cells that plays crucial roles in development and tissue health. The study aims to uncover how cilia are assembled and disassembled, as well as how they facilitate important cellular signaling processes. Using advanced techniques like CRISPR-based screening, the researchers will identify genes that are essential for cilium function and explore their roles in various diseases, including pediatric disorders and cancers. By combining laboratory assays with innovative methods, the research seeks to fill critical gaps in our understanding of cilia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to ciliary defects, including pediatric ciliopathies and specific types of cancer.
Not a fit: Patients without any known ciliary dysfunction or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for diseases related to ciliary dysfunction, such as certain cancers and ciliopathies.
How similar studies have performed: Previous research has shown promising results in understanding ciliary functions and their implications in various diseases, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Breslow, David King — Yale University
- Study coordinator: Breslow, David King
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.