Understanding how primary cilia affect the growth of lymphatic vessels
Official title: Primary Cilia-Dependent Mechanisms of Lymphangiogenesis
Funded at South Dakota State University · NIH-11035192 · Data updated 2026-11-12
This study is looking at how tiny structures called primary cilia help form and control lymphatic vessels, which are important for keeping our body's fluids balanced and supporting our immune system, with the goal of finding new treatments for conditions like lymphedema and issues after corneal transplants.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Dakota State University NIH-funded |
| Lab location | 1 site (Brookings, United States) |
| Project start | March 20, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $353,280 |
| NIH project number | 5P20GM135008-04 |
| Project ID | NIH-11035192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from lymphedema, complications from corneal transplants, or other conditions related to lymphatic vessel dysfunction.
✕Less likely to help
Patients with conditions unrelated to lymphatic vessel function or those who do not have access to the research location may not benefit from this research.
What this research studies
This research investigates the role of primary cilia in the formation and regulation of lymphatic vessels, which are essential for proper fluid and immune responses in the body. By studying how these tiny organelles influence cell signaling and behavior in lymphatic endothelial cells, the researchers aim to uncover new therapeutic strategies for conditions like lymphedema and complications from corneal transplants. The approach includes using knockout mouse models to observe the effects of disrupted primary cilia on lymphangiogenesis, providing insights into potential treatments for patients with lymphatic system disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve wound healing and manage conditions related to lymphatic dysfunction.
How similar studies have gone: While the specific mechanisms involving primary cilia in lymphangiogenesis are being explored, similar research has shown promise in understanding cell signaling pathways in other contexts.
Where this research is happening
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South Dakota State University
Brookings, United States Active
Researchers
- Principal investigator: Fink, Darci M. — South Dakota State University
- Study coordinator: Fink, Darci M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.