Understanding how primary cilia affect tendon healing and development
Official title: Mechanisms of Primary Cilia Regulating Tendon Enthesis Development and Regeneration
Funded at Icahn School of Medicine at Mount Sinai · NIH-10886627 · Data updated 2026-11-12
This study is looking at how tiny structures called primary cilia help tendons heal where they connect to bones, and it aims to find new ways to improve recovery for people with tendon injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $550,096 |
| NIH project number | 5R01AR082797-02 |
| Project ID | NIH-10886627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over the age of 60 who are experiencing rotator cuff tears or similar tendon injuries.
✕Less likely to help
Patients with tendon injuries unrelated to the enthesis or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of primary cilia in the development and healing of tendon enthesis, which is the junction where tendons attach to bones. By exploring how mechanical forces and biochemical signals influence this process, the study aims to uncover the underlying mechanisms that lead to successful tendon repair. The research will utilize advanced biological assays and mechanobiological approaches to analyze how these cilia function as sensors for mechanical and signaling cues during tendon healing. This knowledge could pave the way for new therapeutic strategies to improve outcomes for patients with tendon injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tendon injuries, reducing the high failure rates of current surgical and non-surgical interventions.
How similar studies have gone: While the specific role of primary cilia in tendon healing is still being explored, similar research has shown promise in understanding mechanotransduction in other tissues.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Fang, Fei — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fang, Fei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.