Understanding how primary cilia affect kidney cyst formation in a genetic kidney disease
Role of primary cilium-generated signaling in polycystic kidney disease
This study is looking at how tiny hair-like structures in your kidney cells, called primary cilia, might affect the growth of cysts in autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding new ways to help improve treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10982499 on NIH RePORTER |
What this research studies
This research investigates the role of primary cilia in the development of cysts in autosomal dominant polycystic kidney disease (ADPKD). Researchers will explore how signals generated by these cilia influence the growth of cysts in the kidneys, which are fluid-filled sacs that can lead to kidney failure. By focusing on specific proteins involved in ciliary signaling, the study aims to uncover new therapeutic targets that could improve treatment options for patients with ADPKD. The approach includes studying the trafficking of proteins within cilia to better understand their role in cyst formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease.
Not a fit: Patients without a diagnosis of autosomal dominant polycystic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively slow or prevent the progression of kidney cysts in patients with ADPKD.
How similar studies have performed: Previous research has shown that targeting ciliary signaling pathways can lead to improvements in related conditions, suggesting potential success for this approach in ADPKD.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mukhopadhyay, Saikat — Ut Southwestern Medical Center
- Study coordinator: Mukhopadhyay, Saikat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.