Understanding how previous pregnancies affect future pregnancy outcomes
Official title: Parity, paternity and pregnancy outcomes
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11111334 · Data updated 2026-11-12
This study is looking at how having previous pregnancies might help with future pregnancies and how the immune system reacts to babies during those times, so it’s for anyone interested in understanding how past pregnancies can lead to healthier outcomes for both moms and babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $631,863 |
| NIH project number | 5R01AI184537-02 |
| Project ID | NIH-11111334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women who have experienced complications in previous pregnancies or are planning future pregnancies.
✕Less likely to help
Patients who have never been pregnant or those who are not planning to become pregnant may not benefit from this research.
What this research studies
This research investigates the relationship between prior pregnancies and complications in future pregnancies, focusing on how the immune system responds to fetal antigens. By studying both human epidemiological data and mouse models, the research aims to uncover the protective benefits of previous pregnancies and how changes in paternity can influence these outcomes. The approach includes tracking specific immune cells that may play a role in preventing complications during pregnancy. This could lead to new strategies for improving pregnancy outcomes and reducing infant mortality.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing complications in pregnancies, ultimately reducing infant mortality rates.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in pregnancy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Way, Sing Sing — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Way, Sing Sing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.