Understanding how preTCRs function in T cell development
Ligand-dependent preTCR function
['FUNDING_P01'] · DANA-FARBER CANCER INST · NIH-10877947
This study is looking at how special receptors on developing T cells help them learn to tell the difference between the body’s own cells and harmful invaders, which is important for a healthy immune system, and it could help us find new ways to treat autoimmune diseases.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10877947 on ClinicalTrials.gov |
What this research studies
This research investigates the role of preT cell receptors (preTCRs) in the development of T cells, which are crucial for the immune system's ability to distinguish between self and non-self. The study focuses on how these receptors interact with specific ligands and how this interaction influences T cell maturation in the thymus. By utilizing advanced techniques such as NMR spectroscopy and biomembrane force probes, the researchers aim to uncover the mechanobiological aspects of preTCR signaling and its impact on T cell development. This could lead to a better understanding of immune responses and potential therapeutic targets for autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune disorders or those interested in the mechanisms of immune system function.
Not a fit: Patients with established T cell-related conditions that do not involve the thymus or preTCR function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of T cell development and lead to improved treatments for autoimmune conditions.
How similar studies have performed: Previous research has shown promising results in understanding T cell receptor signaling, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REINHERZ, ELLIS L — DANA-FARBER CANCER INST
- Study coordinator: REINHERZ, ELLIS L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.