Understanding how presynaptic mechanisms affect learning and memory
Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11053544
This study is looking at how certain brain cells change to help us learn and remember things, and it's for anyone interested in understanding more about how our brains work and how this might relate to memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11053544 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that govern presynaptic plasticity, which is crucial for learning and memory. By employing advanced techniques such as proteomics, genome editing, and optogenetics, the team aims to identify the signaling molecules involved in presynaptic function. This study will explore how these mechanisms operate in different types of neurons and how they influence behavior. The findings could pave the way for new insights into brain disorders related to memory and learning.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that impact cognitive functions, such as memory disorders.
Not a fit: Patients with purely physical health issues unrelated to cognitive function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain disorders that affect learning and memory.
How similar studies have performed: Previous research has shown promising results in understanding presynaptic mechanisms, indicating that this approach could yield significant insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SODERLING, SCOTT H — DUKE UNIVERSITY
- Study coordinator: SODERLING, SCOTT H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.