Understanding how pregnancy and infections affect drug absorption and metabolism
A Systems Pharmacology approach to predict the effects of pregnancy and infectious diseases on transporter-mediated drug disposition
This study is looking at how pregnancy and infections affect how your body processes medications, so we can better understand the best ways to safely give drugs to pregnant women who might be sick.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10836392 on NIH RePORTER |
What this research studies
This research investigates how pregnancy and infectious diseases influence the way drugs are absorbed and metabolized in the body. By using a systems pharmacology approach, the study aims to predict changes in drug pharmacokinetics caused by these conditions. It combines clinical pharmacokinetic studies with laboratory data to develop models that can generalize across different drugs and transporters. This is particularly important for designing safe and effective dosing regimens for pregnant women who may be dealing with infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are experiencing infectious diseases.
Not a fit: Patients who are not pregnant or do not have infectious diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and safer medication dosing for pregnant women with infectious diseases.
How similar studies have performed: Previous research has shown success in understanding drug metabolism changes during pregnancy, but this specific approach to transporter-mediated drug disposition is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Unadkat, Jashvant D — University of Washington
- Study coordinator: Unadkat, Jashvant D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.