Understanding how pregnancy affects immune responses to tuberculosis in women with HIV
DYNAMICS OF M. TUBERCULOSIS-SPECIFIC INNATE AND ADAPTIVE IMMUNITY DURING PREGNANCY AND POSTPARTUM IN WOMEN WITH HIV
This study looks at how being pregnant affects the immune system's ability to fight tuberculosis (TB) in women who are living with HIV, aiming to find better ways to protect these women from TB.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10674692 on NIH RePORTER |
What this research studies
This research investigates the dynamics of immune responses to tuberculosis (TB) in pregnant women living with HIV. It focuses on how pregnancy influences specific immune cells and responses that are crucial for fighting TB. By analyzing blood samples from women who participated in a previous study, the research aims to understand the balance between protective immunity and immune suppression during and after pregnancy. This could help identify the best strategies for preventing TB in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women living with HIV, particularly those in areas with high rates of tuberculosis.
Not a fit: Patients who are not pregnant or do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for tuberculosis in pregnant women with HIV, potentially reducing morbidity and mortality.
How similar studies have performed: Previous research has shown that understanding immune responses during pregnancy can lead to better health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Weinberg, Adriana — University of Colorado Denver
- Study coordinator: Weinberg, Adriana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.