Understanding how precancerous lesions in the mouth turn into invasive cancer
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition
This study is looking at how a common mouth condition called oral leukoplakia can turn into a serious type of cancer, and it's for people with oral leukoplakia who want to learn more about their condition and how to catch any changes early.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10930096 on NIH RePORTER |
What this research studies
This research investigates the transition of oral leukoplakia, a common precancerous condition, into oral squamous cell carcinoma, a lethal form of head and neck cancer. By examining the genetic and immune factors involved in this transition, the study aims to identify critical markers that could help in early detection and prevention of invasive cancer. Patients with oral leukoplakia may be monitored through histological and molecular evaluations to understand the progression of their condition. The goal is to develop strategies to intercept this deadly cancer at its earliest stages.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral leukoplakia or those at high risk for developing oral squamous cell carcinoma.
Not a fit: Patients who do not have oral leukoplakia or are not at risk for head and neck cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for patients at risk of developing invasive oral cancer.
How similar studies have performed: Previous research has shown promise in understanding the genetic and immunological factors in cancer progression, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Alexandrov, Ludmil B — University of California, San Diego
- Study coordinator: Alexandrov, Ludmil B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.