Understanding how preadipocytes develop into fat cells
Official title: Investigation of the preadipocyte primary cilia signalosome
Funded at University of Utah · NIH-10903151 · Data updated 2026-11-12
This study is looking at how tiny structures called primary cilia in fat precursor cells might help these cells turn into mature fat cells, with the goal of finding ways to promote healthier fat development and potentially improve treatments for obesity and related health problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $40,207 |
| NIH project number | 1F31DK139738-01 |
| Project ID | NIH-10903151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are struggling with obesity or related metabolic conditions, particularly those interested in understanding the biological mechanisms behind fat cell development.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of primary cilia in preadipocytes, which are cells that can develop into fat cells. The study aims to understand how these cilia influence the differentiation process of preadipocytes into mature adipocytes, particularly focusing on the signaling pathways involved. By examining the ciliary signaling components and their effects on cellular cAMP levels, the research seeks to identify mechanisms that could promote healthier fat cell development, potentially mitigating obesity-related health issues. Patients may benefit from insights that could lead to new treatments for obesity and related metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthier fat cell development, potentially reducing obesity and its associated health risks.
How similar studies have gone: While the specific focus on ciliary signaling in preadipocytes is relatively novel, similar research has shown promising results in understanding cell signaling pathways in other contexts.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Lee, Mark David — University of Utah
- Study coordinator: Lee, Mark David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.