Understanding how pre-cancer cells interact with the immune system in colorectal cancer.
Co-Evolution Mechanisms of Pre-Cancer-Immune Interactions in Shaping Adaptive Cytotoxicity and Myeloid-Derived Suppression
This study is looking at how early-stage cells in colorectal cancer interact with the immune system to better understand how they change and avoid being spotted by the body’s defenses, which could help improve ways to prevent and treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10926865 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between pre-cancerous cells and the immune system in colorectal cancer. By examining human tumor specimens, the study aims to identify how these cells evolve and evade immune detection during the critical transition from pre-cancer to cancer. Utilizing advanced spatial profiling technologies, researchers will model different pathways of pre-cancer progression, focusing on genetic and environmental factors that influence tumor behavior. This work seeks to enhance our understanding of the immune response and its implications for cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for colorectal cancer, particularly those with pre-cancerous lesions.
Not a fit: Patients with advanced colorectal cancer or those without any pre-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and prevention of colorectal cancer.
How similar studies have performed: Previous research has shown promise in understanding immune-tumor interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lau, Ken S — Vanderbilt University Medical Center
- Study coordinator: Lau, Ken S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.