Understanding how pre-cancer and the immune system interact in colorectal cancer
Co-Evolution Mechanisms of Pre-Cancer-Immune Interactions in Shaping Adaptive Cytotoxicity and Myeloid-Derived Suppression
This research looks at how the body's immune system and pre-cancer cells in the colon interact, hoping to find better ways to prevent colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11176217 on NIH RePORTER |
What this research studies
We are exploring the critical stage when pre-cancerous cells in the colon might turn into full-blown cancer. This process is like an 'evolutionary arms race' where the immune system tries to fight off abnormal cells, while these cells try to escape detection and destruction. By studying human tumor samples, we aim to understand the genetic and environmental factors that drive this transition. We will look at different types of pre-cancers to build a complete picture of how they evolve into malignancy. Our goal is to uncover new insights that could lead to improved prevention and monitoring strategies for colorectal cancer.
Who could benefit from this research
Good fit: This research is relevant to patients with colorectal pre-cancer or early-stage colorectal cancer, particularly those whose tissue samples may contribute to understanding disease progression.
Not a fit: Patients without colorectal pre-cancer or cancer may not directly benefit from this specific research, as it focuses on the disease's early stages.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict which pre-cancers are most likely to become cancerous, allowing for earlier intervention and better prevention strategies for colorectal cancer.
How similar studies have performed: Previous work by this team has created a 'pre-cancer atlas,' providing a foundation for this deeper exploration into the immune environment.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lau, Ken S — Vanderbilt University Medical Center
- Study coordinator: Lau, Ken S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.