Understanding how PRDM15 affects blood cell development and blood cancers
DISSECTING THE ROLE OF PRDM15 IN NORMAL HEMATOPOIESIS AND B-CELL MALIGNANCIES
This study is looking at a protein called PRDM15 to see how it affects blood cell development and its role in certain blood cancers like B cell non-Hodgkin lymphoma, with the hope of finding new ways to treat and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10992688 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, PRDM15, in the development of blood cells and its involvement in certain blood cancers, particularly B cell non-Hodgkin lymphoma. The researchers aim to understand how PRDM15 influences the behavior of cancer cells and whether targeting this protein could lead to new treatment strategies. By studying the effects of depleting PRDM15 in pre-cancerous cells, the team hopes to find ways to delay the onset of lymphoma and improve patient outcomes. The approach includes analyzing the molecular pathways regulated by PRDM15 to identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with B cell non-Hodgkin lymphoma or those at risk of developing this type of cancer.
Not a fit: Patients with other types of cancers or those without B cell malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with B cell malignancies.
How similar studies have performed: Previous research has shown promise in targeting similar proteins for cancer treatment, indicating that this approach could be viable.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Guccione, Ernesto — Icahn School of Medicine at Mount Sinai
- Study coordinator: Guccione, Ernesto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.