Understanding how PRC1 overexpression affects cell division mechanics in cancer.
Official title: Defining the Mechanistic Impact of PRC1 Overexpression on Mammalian Spindle Mechanics
Funded at University of California, San Francisco · NIH-10902625 · Data updated 2026-11-12
This study is looking at a protein called PRC1 that helps cells divide, to see how too much of it might affect the way cells separate their chromosomes, which could help us understand some of the problems in cancer, like why some tumors are hard to treat.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,493 |
| NIH project number | 1F31CA291047-01 |
| Project ID | NIH-10902625 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers characterized by chromosomal instability or aneuploidy.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers do not involve chromosomal instability may not benefit from this research.
What this research studies
This research investigates the role of PRC1, a protein that helps in cell division, particularly during the anaphase stage. It aims to understand how overexpression of PRC1 affects the mechanical functions of the spindle, which is crucial for proper chromosome segregation. By using advanced biophysical tools, the research will explore the dynamics of the spindle in living cells, providing insights into how these processes may contribute to cancer characteristics like chromosomal instability and drug resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cell division, potentially improving treatment outcomes for patients with aneuploid cancers.
How similar studies have gone: Other research has shown promising results in understanding the mechanics of cell division in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mullin-Bernstein, Zachary — University of California, San Francisco
- Study coordinator: Mullin-Bernstein, Zachary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.