Understanding how PP2A phosphatase mutations cause diseases
Official title: Structural basis of PP2A phosphatase diseases
Funded at University of Wisconsin-Madison · NIH-10907816 · Data updated 2026-11-12
This study is looking at how a protein called PP2A works in diseases like cancer and brain disorders, to help find better ways to diagnose and treat people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $361,963 |
| NIH project number | 5R01GM145811-02 |
| Project ID | NIH-10907816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with specific types of cancer or neurological disorders associated with PP2A mutations.
✕Less likely to help
Patients without any known PP2A mutations or those with unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of Protein Phosphatase 2A (PP2A) in various diseases, particularly cancers and neurological disorders. By utilizing advanced techniques like cryo-electron microscopy and molecular dynamics simulations, the team aims to uncover how mutations in PP2A subunits affect its function and contribute to disease. The research involves analyzing the structures of both normal and mutated forms of PP2A to understand their dynamics and interactions with other proteins. This could lead to better diagnostic and therapeutic strategies for patients with these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from cancers and neurological disorders linked to PP2A mutations.
How similar studies have gone: Previous research has shown promising results in understanding the role of PP2A in diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Xing, Yongna — University of Wisconsin-Madison
- Study coordinator: Xing, Yongna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.