Understanding how PP2A enzymes are recycled and regulated in the body
Structural and Cellular Choreography for Decommissioning and Recycling of PP2A Holoenzymes
This study is looking at how certain enzymes called PP2A might affect Alzheimer's disease and some cancers, with the hope that understanding them better could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10774205 on NIH RePORTER |
What this research studies
This research investigates the role of protein phosphatase 2A (PP2A) enzymes in various biological processes, particularly their involvement in Alzheimer's disease and certain cancers. By using advanced techniques such as electron microscopy and biochemical assays, the study aims to uncover how these enzymes are regulated and recycled within cells. Patients may benefit from insights gained about PP2A's role in disease mechanisms, potentially leading to new therapeutic strategies. The research focuses on understanding the structural and functional dynamics of PP2A holoenzymes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with conditions unrelated to Alzheimer's disease or cancers associated with PP2A may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Alzheimer's disease and certain cancers by targeting the mechanisms of PP2A regulation.
How similar studies have performed: Previous research has shown promising results in understanding the role of PP2A in cellular processes, indicating that this approach has potential for success.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Xing, Yongna — University of Wisconsin-Madison
- Study coordinator: Xing, Yongna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.