Understanding how poxviruses assemble and function in the body
Official title: Comprehensive genetic dissection of poxvirus membrane assembly and function
Funded at Albert Einstein College of Medicine · NIH-10747445 · Data updated 2026-11-12
This study is looking at how certain viruses that can make people sick spread and behave, with the goal of finding ways to create better vaccines and treatments for infections caused by these viruses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $210,000 |
| NIH project number | 5R21AI174037-02 |
| Project ID | NIH-10747445 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of zoonotic infections from poxviruses, particularly those with compromised immune systems.
✕Less likely to help
Patients who are not at risk for poxvirus infections or who have no history of zoonotic diseases may not benefit from this research.
What this research studies
This research investigates the complex biology of orthopoxviruses, which are a group of viruses that can infect mammals and pose a threat to public health. The focus is on understanding how these viruses generate two infectious forms that are crucial for their spread: one that stays within cells and another that can move between them. By using advanced genetic techniques, the researchers aim to identify specific mutations in viral proteins that affect how well the virus can spread and cause disease. This knowledge could lead to better vaccines and therapies against poxvirus infections.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for infections caused by poxviruses.
How similar studies have gone: Previous research has shown success in understanding viral assembly and function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chandran, Kartik — Albert Einstein College of Medicine
- Study coordinator: Chandran, Kartik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.