Understanding how poxviruses affect cell metabolism and immune response
Official title: The role of mTOR dysregulation in poxvirus infection
Funded at Northwestern University at Chicago · NIH-10989875 · Data updated 2026-11-12
This study looks at how monkeypox and similar viruses affect our body's cells and immune system, aiming to find new ways to fight these infections and improve treatments and vaccines for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | November 17, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $637,016 |
| NIH project number | 5R01AI179744-02 |
| Project ID | NIH-10989875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals at risk for poxvirus infections, such as those in outbreak areas or with compromised immune systems.
✕Less likely to help
Patients who are not at risk for poxvirus infections or those with unrelated health conditions may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which poxviruses, including monkeypox, interact with host cell metabolism and immune responses. It focuses on how these viruses manipulate cellular processes to replicate and evade the immune system, particularly through the mTOR signaling pathway. By studying the unique replication cycle of poxviruses, the research aims to uncover new insights into their biology and potential therapeutic targets. Patients may benefit from advancements in antiviral strategies and vaccines developed from this knowledge.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for poxvirus infections.
How similar studies have gone: Previous research has shown success in understanding viral mechanisms and developing antiviral therapies, indicating a promising potential for this approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Walsh, Derek — Northwestern University at Chicago
- Study coordinator: Walsh, Derek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.