Understanding how potassium channels are regulated in the body
Molecular mechanisms of Tandem Pore potassium channel gating and regulation
This study is looking at how certain channels in our cells help keep them stable and working properly, especially in conditions like heart rhythm problems and chronic pain, to find new ways to improve treatments for these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11088931 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control the activity of tandem pore potassium channels, which are crucial for maintaining the electrical stability of cells. By examining how these channels respond to various signals, the study aims to uncover how they influence cellular excitability, particularly in relation to conditions like cardiac arrhythmia and chronic pain. The research employs advanced techniques such as cryo-electron microscopy and mass spectrometry to explore the interactions between these channels and lipids, with the goal of developing better treatments for related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from cardiac arrhythmias, chronic pain, or related disorders.
Not a fit: Patients with conditions unrelated to potassium channel dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for conditions like cardiac arrhythmia and chronic pain.
How similar studies have performed: Previous research has shown promise in targeting potassium channels for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Riegelhaupt, Paul Michael — Weill Medical Coll of Cornell Univ
- Study coordinator: Riegelhaupt, Paul Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.