Understanding how potassium and sodium channels work in cells
Official title: Molecular dynamics studies of K+ and Na+ channels and biomembranes based on a polarizable force field
Funded at University of Chicago · NIH-11019850 · Data updated 2026-11-12
This study is looking at how certain tiny channels in our cells work to help control heart rhythms, which could help people with heart problems understand their condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $715,323 |
| NIH project number | 5R35GM152124-02 |
| Project ID | NIH-11019850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac arrhythmias or other conditions linked to ion channel abnormalities.
✕Less likely to help
Patients with non-cardiac related conditions or those without ion channel dysfunction may not benefit from this research.
What this research studies
This research investigates the fundamental functions of voltage-gated potassium and sodium channels using advanced molecular dynamics simulations. By creating detailed atomic models, the team aims to uncover how these channels allow ions to pass through cell membranes, which is crucial for processes like heart rhythm regulation. The study also explores how the surrounding biological membranes influence these channels' behavior, focusing on factors like ion selectivity and activation mechanisms. Patients may benefit from insights gained into the mechanisms of cardiac arrhythmias and other related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart rhythm disorders and other conditions related to ion channel dysfunction.
How similar studies have gone: Previous research using molecular dynamics simulations has shown promise in understanding ion channel behavior, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Roux, Benoit — University of Chicago
- Study coordinator: Roux, Benoit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.