Understanding how polycystin proteins affect kidney function and disease
Ion Channel Function and Regulation of the Polycystin-1/2 Complex in Kidney Physiology and Polycystic Kidney Disease
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10840982
This study is looking at how certain proteins in the kidneys, called polycystins, work and how changes in these proteins can lead to polycystic kidney disease, with the goal of finding new treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10840982 on ClinicalTrials.gov |
What this research studies
This research investigates the role of polycystin proteins, specifically PC1 and PC2, in kidney physiology and the development of autosomal dominant polycystic kidney disease (ADPKD). By examining how these proteins function as ion channels and how their mutations lead to disease, the research aims to uncover the mechanisms behind ADPKD. The team will create a new mouse model to study the regulation of these ion channels and their impact on calcium signaling in the kidneys. This work could pave the way for developing targeted therapies for patients with ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
Not a fit: Patients with kidney diseases unrelated to polycystin proteins or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or even reverse the progression of polycystic kidney disease.
How similar studies have performed: Previous research has shown promise in understanding ion channel functions in kidney diseases, indicating that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QIAN, FENG — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: QIAN, FENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.