Understanding how pneumonia affects the body's response to treatment
Administrative Core
This study is looking at how the body and germs interact in the lungs of people with serious pneumonia to understand why some patients don’t get better with treatment, and it’s designed for anyone interested in improving care for pneumonia patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11014072 on NIH RePORTER |
What this research studies
This research focuses on the complex interactions between the body and pathogens at the alveolar level, specifically in cases of serious pneumonia. By utilizing advanced systems biology techniques, the project aims to identify why some patients do not respond well to therapy. The approach includes high-throughput omics methods and mathematical modeling to guide experiments and improve understanding of these interactions. The Administrative Core plays a crucial role in facilitating communication and collaboration among researchers to ensure effective data sharing and integration.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with serious pneumonia who may be experiencing ineffective responses to current therapies.
Not a fit: Patients with mild pneumonia or those who do not have complications related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from pneumonia.
How similar studies have performed: Previous research in systems biology and host/pathogen interactions has shown promise in improving treatment outcomes for infectious diseases, suggesting that this approach could be beneficial.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Wunderink, Richard G — Northwestern University at Chicago
- Study coordinator: Wunderink, Richard G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.