Understanding how PLGA implants release medication in the body
Developing PBPK-model based mechanistic IVIVC for PLGA implants
This study is looking at a new way to predict how long-lasting implants that release medication work, which could help create better treatments for patients who need long-acting injections, like those using buprenorphine.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11063705 on NIH RePORTER |
What this research studies
This research focuses on developing a method to predict how long-acting PLGA-based implants release medication over time. By using a physiologically based pharmacokinetic (PBPK) modeling approach, the team aims to analyze how different formulation parameters affect the release of the drug both in laboratory settings and in the body. Patients may benefit from improved long-acting injectable treatments that are more effective and tailored to individual needs. The research will involve creating a new testing method to evaluate the release of buprenorphine from these implants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who require long-term pain management or treatment for opioid dependence.
Not a fit: Patients who do not require long-acting injectable treatments or those with contraindications to PLGA implants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective long-acting injectable treatments for patients.
How similar studies have performed: Previous research has shown promise in using PBPK modeling for drug release predictions, indicating potential success for this approach.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Zhang, Feng — University of Texas at Austin
- Study coordinator: Zhang, Feng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.