Understanding how platelets produce proteins and respond to signals in the blood
Function and regulation of constitutive protein translation in platelets
This study is looking at how platelets, which are important for blood clotting, work with proteins and hormones in your blood to understand their role in keeping your blood vessels healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10843949 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which platelets, a type of blood cell, initiate protein translation and respond to growth factors and hormones in the bloodstream. The study aims to map the proteins present in platelets and understand how these proteins affect platelet function and reactivity. By examining the role of specific molecules like ARGONAUTE2 in regulating platelet behavior, the research seeks to uncover new insights into how platelets contribute to blood clotting and overall vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with disorders affecting platelet function or those at risk for bleeding or thrombotic events.
Not a fit: Patients with stable platelet function and no history of bleeding or clotting disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to blood clotting and hemorrhage.
How similar studies have performed: Previous research has shown that understanding platelet biology can lead to significant advancements in treating blood-related conditions, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Goldfinger, Lawrence E — Thomas Jefferson University
- Study coordinator: Goldfinger, Lawrence E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.