Understanding how platelets interact with fibrin to improve blood clotting
Official title: Dissecting the Mechanims of Platelet-Fibrin interaction
Funded at Rockefeller University · NIH-10914262 · Data updated 2026-11-12
This study is looking at how platelets, which help your blood clot, interact with a protein called fibrin, and it's trying to find new ways to prevent unwanted blood clots, which could help people with bleeding and clotting issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $139,120 |
| NIH project number | 5K01HL169359-02 |
| Project ID | NIH-10914262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals over 21 years old who have conditions related to blood clotting or bleeding.
✕Less likely to help
Patients with conditions unrelated to platelet function or blood coagulation may not benefit from this research.
What this research studies
This research investigates the mechanisms by which platelets interact with fibrin, a protein essential for blood clotting. By developing innovative assays, the study aims to differentiate between platelet interactions with fibrinogen and polymerized fibrin, which are crucial for effective clot retraction and stabilization. The research employs high-throughput screening to identify compounds that can inhibit unwanted clot retraction, potentially leading to new treatments for thrombotic conditions. Patients may benefit from insights gained about how to better manage bleeding and clotting disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with bleeding disorders or those at risk of thrombosis.
How similar studies have gone: Previous research has shown promise in understanding platelet interactions, but this approach offers novel insights that have not been extensively tested.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Buitrago, Claudia Lorena — Rockefeller University
- Study coordinator: Buitrago, Claudia Lorena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.