Understanding how platelets behave during inflammation and sepsis
Platelet Reprogramming During Inflammation
['FUNDING_OTHER'] · VA SALT LAKE CITY HEALTHCARE SYSTEM · NIH-11043314
This study is looking at how platelets, which are tiny cells in your blood, behave during inflammation and sepsis, especially when a substance called interferon alpha is high, to find out why they sometimes don’t work properly and how that can lead to serious problems, with the goal of discovering new ways to help people who are dealing with these health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA SALT LAKE CITY HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11043314 on ClinicalTrials.gov |
What this research studies
This research investigates the role of platelets in inflammation and sepsis, focusing on how they respond to interferon alpha (IFNα), which is elevated during these conditions. The study aims to uncover the molecular mechanisms behind platelet dysfunction and their contribution to complications like thrombosis, organ failure, and increased cardiovascular risks. By examining how platelets and their precursor cells, megakaryocytes, manage protein secretion during inflammatory stress, the research seeks to identify new pathways that could lead to better treatments for patients suffering from sepsis and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients experiencing sepsis or severe inflammation, particularly those at risk for thrombotic events.
Not a fit: Patients with stable chronic conditions unrelated to inflammation or sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that reduce the risk of thrombosis and other complications in patients with sepsis.
How similar studies have performed: Previous research has shown that targeting platelet responses during inflammation can lead to significant improvements in patient outcomes, indicating that this approach has potential for success.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- VA SALT LAKE CITY HEALTHCARE SYSTEM — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RONDINA, MATTHEW THOMAS — VA SALT LAKE CITY HEALTHCARE SYSTEM
- Study coordinator: RONDINA, MATTHEW THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.